Molecular activities, biosynthesis and evolution of triterpenoid saponins
JM Augustin, V Kuzina, SB Andersen, S Bak - Phytochemistry, 2011 - Elsevier
Saponins are bioactive compounds generally considered to be produced by plants to
counteract pathogens and herbivores. Besides their role in plant defense, saponins are of …
counteract pathogens and herbivores. Besides their role in plant defense, saponins are of …
[HTML][HTML] Triterpenes as potentially cytotoxic compounds
M Chudzik, I Korzonek-Szlacheta, W Król - Molecules, 2015 - mdpi.com
Triterpenes are compounds of natural origin, which have numerously biological activities:
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …
Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance
T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
Betulinic acid and its derivatives: A patent review (2008–2013)
R Csuk - Expert opinion on therapeutic patents, 2014 - Taylor & Francis
Introduction: Betulinic acid (BA) is a triterpenoid that can be obtained from renewable
resources. BA is cytotoxic to many human tumor cell lines mainly by apoptosis but cell death …
resources. BA is cytotoxic to many human tumor cell lines mainly by apoptosis but cell death …
Chemistry and pharmacology of saponins: special focus on cytotoxic properties
Saponins are bioactive compounds produced mainly by plants but also by some marine
organisms and insects. In the recent past, there has been unforeseen interest in the clinical …
organisms and insects. In the recent past, there has been unforeseen interest in the clinical …
Chemical synthesis of saponins
Y Yang, S Laval, B Yu - Advances in carbohydrate chemistry and …, 2014 - Elsevier
Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in
plants and some marine organisms. By expressing a large diversity of structures on both …
plants and some marine organisms. By expressing a large diversity of structures on both …
[HTML][HTML] Allobetulin and its derivatives: synthesis and biological activity
W Dehaen, AA Mashentseva, TS Seitembetov - Molecules, 2011 - mdpi.com
This review covers the chemistry of allobetulin analogs, including their formation by
rearrangement from betulin derivatives, their further derivatisation, their fusion with …
rearrangement from betulin derivatives, their further derivatisation, their fusion with …
[HTML][HTML] Contribuição da fitoquímica para o desenvolvimento de um país emergente
R Braz Filho - Química Nova, 2010 - SciELO Brasil
The sustainable development of an emergent country is dependent on a consistent
scientific, technologic and innovative policy, on nature and biodiversity, on a rational …
scientific, technologic and innovative policy, on nature and biodiversity, on a rational …
[HTML][HTML] Glycosylated triterpenoids as endosomal escape enhancers in targeted tumor therapies
H Fuchs, N Niesler, A Trautner, S Sama, G Jerz… - Biomedicines, 2017 - mdpi.com
Protein-based targeted toxins play an increasingly important role in targeted tumor
therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major …
therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major …
Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability
OV Tsepaeva, TI Salikhova, RA Ishkaeva… - Journal of Natural …, 2023 - ACS Publications
A convenient synthesis is presented for a new class of bioactive bifunctionalized conjugates
of lupane-type triterpenoids with triphenylphosphonium (TPP) and glycopyranosyl targeting …
of lupane-type triterpenoids with triphenylphosphonium (TPP) and glycopyranosyl targeting …