Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell
types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Matrix metalloproteases are secreted by mammalian cells as zymogens and, upon
activation, initiate tissue remodeling by proteolytic degradation of collagens and …

Amyloid-β (Aβ) appears critical to Alzheimer's disease. To clarify possible mechanisms of Aβ
action, we have quantified Aβ-induced gene expression in vitro by using Aβ-treated primary …

Metastatic tumours to the oral region are uncommon. There are more published cases of
jawbone métastases than in oral soft tissues. The most common primary sources of …

FGFs are pleiotropic growth factors that control cell proliferation, migration and
differentiation. However, FGF transduction studies have so far focused primarily on the …

Changes in the hemostatic system and chronic hemostatic activation are frequently
observed in patients with cancer, even in the absence of venous thromboembolism (VTE) …

Although the bidirectional association between cancer and venous thromboembolism (VTE)
has been known for almost two centuries, recent advances in our understanding of the …

The pro-inflammatory cytokines IL-1 and TNF-α are primary mediators of the acute phase
response, the complex reaction of the mammalian organism to infection and injury. Among …

We examined the expression of tissue factor (TF) and vascular endothelial growth factor
(VEGF) and the microvessel density (MVD) in 100 patients with colorectal cancer, and we …