Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

Obesity represents a major medical and public health problem worldwide. Efforts have been
made to develop novel treatments, and among them bariatric surgery is used as an effective …

Binge alcohol (ethanol) drinking is a destructive pattern of ethanol consumption that may
precipitate ethanol dependence—a chronic, debilitating, and prevalent health problem …

Background Binge drinking, characterized by heavy episodic alcohol consumption, poses
significant health hazards and increases the likelihood of developing an alcohol use …

summary Alcohol dependence is a common mental disorder that is associated with
substantial disease burden. Current efforts at prevention and treatment of alcohol …

Anorexia nervosa (AN) is an eating disorder characterized by severe hypophagia and
weight loss, and an intense fear of weight gain. Activity-based anorexia (ABA) refers to the …

In this chapter, we review the effects of global null mutant and overexpressing transgenic
mouse lines on voluntary self-administration of alcohol. We examine approximately 200 …

Frequent binge drinking has been linked to heart disease, high blood pressure, type 2
diabetes, and the development of ethanol dependence. Thus, identifying pharmaceutical …

Understanding factors that contribute to the escalation of alcohol consumption is key to
understanding how an individual transitions from non/social drinking to AUD and to …

D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2
receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of …