Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of
chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the …

European guideline on indications, performance and clinical impact of 13C‐breath tests in adult and pediatric patients: An EAGEN, ESNM, and ESPGHAN consensus …

J Keller, HF Hammer, PR Afolabi, M Benninga… - UEG …, 2021 - Wiley Online Library
Introduction 13C‐breath tests are valuable, noninvasive diagnostic tests that can be widely
applied for the assessment of gastroenterological symptoms and diseases. Currently, the …

Biopsy and noninvasive methods to assess progression of nonalcoholic fatty liver disease

P Bedossa, K Patel - Gastroenterology, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of histopathologic features,
ranging from isolated hepatic steatosis, to steatohepatitis with evidence of hepatocellular …

Screening strategy for non-alcoholic fatty liver disease

S Zhang, LY Mak, MF Yuen… - Clinical and molecular …, 2022 - pmc.ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease,
affecting approximately 25% of the general population worldwide, and is forecasted to …

Targeted breath analysis: exogenous volatile organic compounds (EVOC) as metabolic pathway-specific probes

E Gaude, MK Nakhleh, S Patassini… - Journal of Breath …, 2019 - iopscience.iop.org
Breath research has almost invariably focussed on the identification of endogenous volatile
organic compounds (VOCs) as disease biomarkers. After five decades, a very limited …

Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function

KL Thomsen, H Grønbæk, E Glavind… - American Journal …, 2014 - journals.physiology.org
Nonalcoholic steatohepatitis (NASH) is increasing in prevalence, yet its consequences for
liver function are unknown. We studied ureagenesis, an essential metabolic liver function of …

13C Methacetin Breath Test for Assessment of Microsomal Liver Function: Methodology and Clinical Application

K Gorowska-Kowolik, A Chobot… - … research and practice, 2017 - Wiley Online Library
Assessment of the liver function, and the need of constant monitoring of the organ's capacity,
concerns not only patients with primary liver diseases, but also those at risk of hepatopathies …

Non‐alcoholic fatty liver disease in obese adults: clinical aspects and current management strategies

M Pallayova, S Taheri - Clinical Obesity, 2014 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder whose
prevalence is strongly linked to the current epidemic of obesity in many western countries …

Non-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions

PL Eriksen, M Soerensen, H Grønbæk… - Clinics and Research in …, 2019 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a major health concern affecting
25% of the world's population. It is generally held that a fatty liver does not influence liver …

Kinetic validation of the LiMAx test during 10 000 intravenous 13C-methacetin breath tests

TM Rubin, K Heyne, A Luchterhand… - Journal of breath …, 2017 - iopscience.iop.org
The maximal liver function capacity (LiMAx) test, a novel 13 C-methacetin breath test, has
proven clinical validity in determining hepatic metabolic capacity. In contrast to prior 13 C …