Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate …
MD Hellmann, JE Chaft, WN William, V Rusch… - The lancet …, 2014 - thelancet.com
Improvements in outcomes for patients with resectable lung cancers have plateaued.
Clinical trials of resectable non-small-cell lung cancers with overall survival as the primary …
Clinical trials of resectable non-small-cell lung cancers with overall survival as the primary …
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
B Hemmingsen, SS Lund, C Gluud… - Cochrane Database …, 2013 - cochranelibrary.com
Background Patients with type 2 diabetes mellitus (T2D) have an increased risk of
cardiovascular disease and mortality compared to the background population …
cardiovascular disease and mortality compared to the background population …
[HTML][HTML] International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): position statement and 10 recommendations for action
Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …
which is now a significant cause of mortality, morbidity, and disability that has reached …
The strength of association between surrogate end points and survival in oncology: a systematic review of trial-level meta-analyses
Importance The strength of association between surrogate end points and survival in
oncology is important to understand because surrogate end points are frequently used in …
oncology is important to understand because surrogate end points are frequently used in …
New clinical trial designs in the era of precision medicine: an overview of definitions, strengths, weaknesses, and current use in oncology
With expanding knowledge in tumor biology and biomarkers, oncology therapies are
increasingly moving away from the “one-size-fits-all” rationale onto biomarker-driven …
increasingly moving away from the “one-size-fits-all” rationale onto biomarker-driven …
[HTML][HTML] Development, testing and use of data extraction forms in systematic reviews: a review of methodological guidance
RB Büchter, A Weise, D Pieper - BMC medical research methodology, 2020 - Springer
Background Data extraction forms link systematic reviews with primary research and provide
the foundation for appraising, analysing, summarising and interpreting a body of evidence …
the foundation for appraising, analysing, summarising and interpreting a body of evidence …
Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients
R Parke, S McGuinness, R Dixon… - British journal of …, 2013 - academic.oup.com
Background Respiratory complications after cardiac surgery increase morbidity, mortality,
and length of stay. Studies suggest that routine delivery of positive airway pressure after …
and length of stay. Studies suggest that routine delivery of positive airway pressure after …
[HTML][HTML] Time to review the role of surrogate end points in health policy: state of the art and the way forward
The efficacy of medicines, medical devices, and other health technologies should be proved
in trials that assess final patient-relevant outcomes such as survival or morbidity. Market …
in trials that assess final patient-relevant outcomes such as survival or morbidity. Market …
Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial …
Purpose To assess the effects of stress ulcer prophylaxis (SUP) versus placebo or no
prophylaxis on all-cause mortality, gastrointestinal (GI) bleeding and hospital-acquired …
prophylaxis on all-cause mortality, gastrointestinal (GI) bleeding and hospital-acquired …
The assessment and appraisal of regenerative medicines and cell therapy products: an exploration of methods for review, economic evaluation and appraisal
BACKGROUND: The National Institute for Health and Care Excellence (NICE)
commissioned a'mock technology appraisal'to assess whether changes to its methods and …
commissioned a'mock technology appraisal'to assess whether changes to its methods and …