Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
Neuroinflammation in bipolar depression
F Benedetti, V Aggio, ML Pratesi, G Greco… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of …
Importance It is unclear whether differences exist in the magnitude and variability of pro-
inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects …
inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects …
The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …
between genetic and environmental risk factors. The immune system is now known to play …
Cytokine alterations in schizophrenia: an updated review
S Momtazmanesh, A Zare-Shahabadi… - Frontiers in …, 2019 - frontiersin.org
Schizophrenia, a multisystem disorder with an unknown etiology, is associated with several
immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we …
immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we …
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …
subset of people with schizophrenia, with significant increases in inflammatory markers …
Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …
nervous system. During fetal development, the initial colonization of the microbiome …
[HTML][HTML] Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity
Objective Immune system dysfunction is hypothesised to contribute to structural brain
changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed …
changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed …
Anti-inflammatory effects of 2nd generation antipsychotics in patients with schizophrenia: A systematic review and meta-analysis
Background Schizophrenia is a major psychiatric disorder with unknown aetiology. Recent
evidence suggests a potential role for cytokines in its pathophysiology and that antipsychotic …
evidence suggests a potential role for cytokines in its pathophysiology and that antipsychotic …
Increased macrophages and C1qA, C3, C4 transcripts in the midbrain of people with schizophrenia
TD Purves-Tyson, K Robinson, AM Brown… - Frontiers in …, 2020 - frontiersin.org
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …
dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of …