Molecular and cellular mechanisms of castration resistant prostate cancer

Y Huang, X Jiang, X Liang, G Jiang - Oncology letters, 2018 - spandidos-publications.com
With increases in the mortality rate and number of patients with prostate cancer (PCa), PCa,
particularly the advanced and metastatic disease, has been the focus of a number of studies …

The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

JC Evans, M Malhotra, JF Cryan… - British journal of …, 2016 - Wiley Online Library
Prostate specific membrane antigen (PSMA) otherwise known as glutamate
carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in …

A novel role of prostate-specific membrane antigen in telomere stability in prostate cancer cells

V Reddy, C Hwang, GPV Reddy, SH Kim - Molecular Cancer Research, 2023 - AACR
Prostate-specific membrane antigen (PSMA) expression increases with prostate cancer
grade and progression; however, the role of PSMA in prostate cancer progression remains …

Folate-targeted amphiphilic cyclodextrin. siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and …

JC Evans, M Malhotra, J Guo, JP O'Shea… - … , Biology and Medicine, 2016 - Elsevier
In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-
formulating CD. siRNA complexes with DSPE-PEG 5000-folate to target the prostate specific …

Prostate specific membrane antigen (PSMA): a novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells

Y Zhang, Z Guo, T Du, J Chen, W Wang, K Xu… - The …, 2013 - Wiley Online Library
BACKGROUND Regulated activation of p38 is crucial for cell proliferation, survival, and
metabolism. Our previous studies had showed that prostate specific membrane antigen …

MDM2 and PSMA play inhibitory roles in metastatic breast cancer cells through regulation of matrix metalloproteinases

R Bradbury, WG Jiang, YX Cui - Anticancer research, 2016 - ar.iiarjournals.org
Background/Aim: Mouse double minute 2 (MDM2) and prostate-specific membrane antigen
(PSMA) are currently under investigation as individual therapeutic targets due to their …

Prostate specific membrane antigen knockdown impairs the tumorigenicity of LNCaP prostate cancer cells by inhibiting the phosphatidylinositol 3-kinase/Akt signaling …

Z Guo, Y Lai, T Du, Y Zhang, J Chen, L Bi… - Chinese Medical …, 2014 - journals.lww.com
Background Prostate specific membrane antigen (PSMA) can facilitate the growth, migration,
and invasion of the LNCaP prostate cancer cell lines, but the underlying molecular …

ARH3 通过稳定MCM2-7 表达促进神经胶质母细胞瘤增殖

谢晓娟, 胡开顺 - 岭南现代临床外科, 2023 - lingnanwaike.com
目的探讨ADP-核糖水解酶ARH3 在神经胶质母细胞瘤内促进细胞增殖的机制. 方法通过GEPIA2
和CPTAC 数据库分析ARH3 在胶质母细胞瘤中的mRNA 及蛋白水平的表达量; 设计两条siRNA …

[PDF][PDF] 沉默前列腺特异性膜抗原促进前列腺癌LNCAP 细胞上皮-间质转化及迁移, 侵袭的研究

李金, 赖义明, 曾乐祥 - 岭南现代临床外科, 2023 - lingnanwaike.com
目的利用RNAi 技术沉默LNCAP 细胞中前列腺特异性膜抗原(PSMA) 表达并检测表达情况,
检测沉默PSMA 后LNCAP 细胞迁移及侵袭等生物学行为的变化情况, 以及LNCAP 细胞中上皮 …

[引用][C] 前列腺特异性膜抗原通过p38 通路对前列腺癌细胞增殖, 迁移的调控研究

杜涛, 张一鸣, 郭正辉, 陈杰青, 周诗丽, 赖义明, 曹亿… - 中华实验外科杂志, 2013