Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types, and their …

Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to
adjust their synaptic strength in response to changes in activity. Despite the high proximity of …

The function and pharmacology of γ-aminobutyric acid type A receptors (GABAARs) are of
great physiological and clinical importance and have long been thought to be determined by …

Diverse populations of GABA A receptors (GABA A Rs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …

The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic
transmission, synaptic plasticity and the consequent formation of neural circuits during brain …