Most pharmaceutical products are manufactured either by applying a total synthesis
approach or by modifying a naturally occurring product. In both cases, a wide range of …

Process intensification (PI) provides great opportunities to drastically improve the
performance of chemical processes within many branches of chemical industry including the …

Crystallization is an important unit operation in the pharmaceutical industry. At present, most
pharmaceutical crystallization processes are performed in batches. However, due to product …

A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …

Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished
continuously using a cascade of mixed suspension mixed product removal crystallizers in …

This paper presents the first-ever industrial application of the digital design of a complex,
large-scale industrial continuous crystallization network. The aim of the work is to optimize a …

A review of uncertainty quantification techniques is provided for a variety of situations
involving uncertainties in model inputs (independent variables). The situations of interest are …

Precompetitive collaborations on new enabling technologies for research and development
are becoming popular among pharmaceutical companies. The Enabling Technologies …

The continuous crystallization of l-glutamic acid from water in a single-stage mixed-
suspension mixed-product-removal crystallizer coupled to a milling loop is studied. We show …

Antisolvent crystallization is an important purification technology for the pharmaceutical and
fine chemical industries. Herein, we investigated the mass-transfer mechanism of membrane …