The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Heart failure is a global health problem, appearing most commonly in patients with previous
myocardial infarction (MI). Cardiac remodelling, particularly fibrosis, seen in both the …

It is estimated that over 10% of the adult population in developed countries have some
degree of chronic kidney disease (CKD). CKD is a progressive and irreversible deterioration …

Background & Aims: There is a significant relationship between inheritance of high
transforming growth factor (TGF)-β1 and angiotensinogen-producing genotypes and the …

Inflammatory cell infiltration plays a key role in the onset and progression of renal injury. The
NF-κB participates in the inflammatory response, regulating many proinflammatory genes …

Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by
unilateral ureteral obstruction. Unilateral ureteral obstruction (UUO) results in …

The renal community is faced with an ever increasing number of patients reaching end-
stage renal failure. Clinical studies have provided clear evidence that angiotensin …