Chronic inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis.
Both are characterized by inflammation of part of the digestive tract lining. Azathioprine …

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer seen in
children worldwide and in the Middle East. Although there have been major advances in …

Azathioprine (AZA) is a well-known immunosuppressant used for many years for its ability to
ensure long term disease remission in inflammatory bowel diseases (IBD) at an affordable …

Background Mutations of the human FAM111B gene are associated with hereditary fibrosing
poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis (POIKTMP), a rare …

Thiopurines are clinically useful in the management of diverse immunological and malignant
conditions. Nevertheless, these purine analogues can cause lethal myelosuppression …

Background The genetic variants of NUDT15 have been verified to induce adverse events
(AEs) of thiopurines. Codon 139 variants are frequently observed in Asians, while multiple …

Purpose The identification of gene mutations in the modern medical workup of metastatic
spine tumors has become more common but has not been highly utilized in surgical …

BACKGROUND: Azathioprine (AZA) is a widely used immunosuppressant drug. Leukopenia
is a serious adverse effect of the drug which often necessitates dose reduction or drug …

Background Promoter plays important roles in regulating transcription of genes. Association
studies of genetic variants in promoter region with type 2 diabetes (T2D) risk have been …

Background Mucolipidosis alpha/beta is an inborn error of metabolism characterized by
deficiency of GlcNAc-1-phosphotransferase, in which essential alpha/beta subunits are …