Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

Background Trastuzumab resistance followed by metastasis is a major obstacle for
improving the clinical outcome of patients with advanced human epidermal growth factor …

Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

Dysregulation of histone acetylation has been implicated in the onset of age-associated
memory impairment and the pathogenesis of neurodegenerative diseases. Elevation of …

Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline and neuropathological features, including abnormal deposition of amyloid …

Background Resistance to trastuzumab has become a leading cause of mortality in breast
cancer patients and is one of the major obstacles for improving the clinical outcome. Cell …

The Mendelian disorders of the epigenetic machinery are genetic disorders that involve
disruption of the various components of the epigenetic machinery (writers, erasers, readers …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …