[HTML][HTML] Androgen Receptor–Interacting Proteins in Prostate Cancer Development and Therapy Resistance

Z Culig, M Puhr - The American journal of pathology, 2024 - Elsevier
Endocrine therapy for prostate cancer is based on the use of drugs that diminish androgen
concentration and androgen receptor (AR) signaling inhibitors and is limited by the …

Preclinical models in prostate cancer: Resistance to AR targeting therapies in prostate cancer

W Devlies, F Handle, G Devos, S Joniau, F Claessens - Cancers, 2021 - mdpi.com
Simple Summary In this review, we will look into the existing methods to study treatment
resistance to androgen receptor targeted therapies in prostate cancer. This will encompass …

[HTML][HTML] High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1

YS Ma, TM Wu, ZW Lv, GX Lu, XL Cong, RT Xie… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Increasing evidence supports that microRNA (miRNA) plays a significant functional role in
cancer progression by directly regulating respective targets. In this study, the expression …

The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis

Q Chen, P Guo, Y Hong, P Mo, C Yu - Cell & Bioscience, 2024 - Springer
Abstract Steroid receptor coactivator-1 (SRC-1, also known as NCOA1) frequently functions
as a transcriptional coactivator by directly binding to transcription factors and recruiting to the …

In silico investigation of the role of miRNAs in a possible developmental origin of prostate cancer in F1 and F2 offspring of mothers exposed to a phthalate mixture

AM Aquino, MN Fioretto… - Environmental …, 2024 - Wiley Online Library
A previous study using miRNA sequencing revealed that exposure to a mixture of phthalates
during pregnancy and lactation dysregulated rno‐miR‐184 and rno‐miR‐141‐3p in the …

High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa)

J Li, Z Wang, C Tie - Bioengineered, 2021 - Taylor & Francis
Docetaxel resistance is one of the major obstacles that undermine the treatment outcome of
PCa. Exploring molecular mechanisms associated with docetaxel resistance could provide …

The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma

L Wang, W Li, K Li, Y Guo, D Liu, Z Yao, X Lin… - Cancer …, 2018 - Wiley Online Library
Abstract Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene
expression mediated by a wide spectrum of steroid receptors such as androgen receptor …

MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion

J Guo, R Cao, X Yu, Z Xiao, Z Chen - Tumor Biology, 2017 - journals.sagepub.com
The regulation of initiation and progression during carcinogenesis of bladder carcinoma is
not completely elucidated. Dysregulation of microRNAs has been detected to play critical …

AR-dependent phosphorylation and phospho-proteome targets in prostate cancer

VB Venkadakrishnan, S Ben-Salem… - Endocrine-related …, 2020 - erc.bioscientifica.com
Prostate cancer (CaP) is the second leading cause of cancer-related deaths in western men.
Because androgens drive CaP by activating the androgen receptor (AR), blocking AR's …

Non‐coding and coding genomic variants distinguish prostate cancer, castration‐resistant prostate cancer, familial prostate cancer, and metastatic castration‐resistant …

IO Alanazi, ZS Al Shehri, E Ebrahimie… - Molecular …, 2019 - Wiley Online Library
A considerable number of deposited variants has provided new possibilities for knowledge
discovery in different types of prostate cancer. Here, we analyzed variants located on 3 …