Tumor cell invasion in glioblastoma

A Vollmann-Zwerenz, V Leidgens, G Feliciello… - International journal of …, 2020 - mdpi.com
Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

RC Gimple, S Bhargava, D Dixit… - Genes & …, 2019 - genesdev.cshlp.org
Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

N Jiang, B Xie, W Xiao, M Fan, S Xu, Y Duan… - Nature …, 2022 - nature.com
Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25%
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …

[HTML][HTML] Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma

A Bhaduri, E Di Lullo, D Jung, S Müller, EE Crouch… - Cell stem cell, 2020 - cell.com
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor
heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor …

[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers

R Mallick, S Basak, AK Duttaroy - Progress in lipid research, 2021 - Elsevier
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

Personalized immunotherapy against several neuronal and brain tumors

S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Metabolic abnormalities in glioblastoma and metabolic strategies to overcome treatment resistance

W Zhou, DR Wahl - Cancers, 2019 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

LB Hoang‐Minh, FA Siebzehnrubl, C Yang… - The EMBO …, 2018 - embopress.org
Metabolic reprogramming has been described in rapidly growing tumors, which are thought
to mostly contain fast‐cycling cells (FCC s) that have impaired mitochondrial function and …

Fatty acid signaling mechanisms in neural cells: fatty acid receptors

LJ Falomir-Lockhart, GF Cavazzutti… - Frontiers in cellular …, 2019 - frontiersin.org
Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be
stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the …

Maternal supply of both arachidonic and docosahexaenoic acids is required for optimal neurodevelopment

S Basak, R Mallick, A Banerjee, S Pathak, AK Duttaroy - Nutrients, 2021 - mdpi.com
During the last trimester of gestation and for the first 18 months after birth, both
docosahexaenoic acid, 22: 6n-3 (DHA) and arachidonic acid, 20: 4n-6 (ARA) are …