Innovative and rapid antimicrobial susceptibility testing systems

A van Belkum, CAD Burnham, JWA Rossen… - Nature Reviews …, 2020 - nature.com
Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

Emerging digital PCR technology in precision medicine

L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …

Microfluidics for antibiotic susceptibility testing

W Postek, N Pacocha, P Garstecki - Lab on a Chip, 2022 - pubs.rsc.org
The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …

The Laboratory Diagnosis of Neisseria gonorrhoeae: Current Testing and Future Demands

T Meyer, S Buder - Pathogens, 2020 - mdpi.com
The ideal laboratory test to detect Neisseria gonorrhoeae (Ng) should be sensitive, specific,
easy to use, rapid, and affordable and should provide information about susceptibility to …

Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

K Hsieh, JH Melendez, CA Gaydos, TH Wang - Lab on a Chip, 2022 - pubs.rsc.org
The incidence rates of sexually transmitted infections (STIs), including the four major curable
STIs–chlamydia, gonorrhea, trichomoniasis and, syphilis–continue to increase globally …

Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects

D Golparian, M Unemo - Expert Review of Molecular Diagnostics, 2022 - Taylor & Francis
Introduction Several nucleic acid amplification tests (NAATs), mostly PCRs, to detect
antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae are …

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Z Zhu, D Surujon, JC Ortiz-Marquez, W Huo… - Nature …, 2020 - nature.com
Current approaches explore bacterial genes that change transcriptionally upon stress
exposure as diagnostics to predict antibiotic sensitivity. However, transcriptional changes …

Point-by-point progress: gonorrhea point of care tests

CA Gaydos, JH Melendez - Expert review of molecular diagnostics, 2020 - Taylor & Francis
Introduction Point-of-care (POC) tests for Neisseria gonorrhoeae (Ng) are urgently needed
to control the gonorrhea epidemic, so patients can receive immediate diagnoses and …

The impact of long-term antibiotic therapy of cutaneous adverse reactions to EGFR inhibitors in colorectal cancer patients

MM Mihai, A Ion, C Giurcăneanu, C Nițipir… - Journal of Clinical …, 2021 - mdpi.com
Colorectal cancer (CRC) is an important public health issue, in terms of incidence and
mortality, with approximately 1.8 million new cases reported worldwide in 2018 …

Digital electrical impedance analysis for single bacterium sensing and antimicrobial susceptibility testing

B Scherer, C Surrette, H Li, P Torab, E Kvam… - Lab on a Chip, 2021 - pubs.rsc.org
Single-molecule and single-cell analysis techniques have opened new opportunities for
characterizing and analyzing heterogeneity within biological samples. These detection …