During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Kinin peptides are implicated in many physiological and pathological processes, including
the regulation of blood pressure and sodium homeostasis, inflammation and the …

Premenopausal women are much less prone to develop cardiovascular disease than men of
similar age, but this advantage no longer applies after menopause. We previously found that …

Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of
several cardiovascular diseases. Because of its dual role in regulating angiotensin II and …

There are conflicting data about gender differences in cardiac function after myocardial
infarction (MI), including cardiac rupture and mortality. Using a mouse model of MI, we …

Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis, pain
and inflammation. After release from their precursor kininogens, kinins or their C-terminal …

Understanding the physiological role of the plasma kallikrein-kinin system (KKS) has been
hampered by not knowing how the proteins of this proteolytic system, when assembled in …

Inflammation may play an important role in the pathogenesis of cardiac fibrosis in heart
failure (HF) after myocardial infarction (MI). N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is …

We previously found that male mice with myocardial infarction (MI) had a high rate of cardiac
rupture, which generally occurred at 3 to 5 days after MI. Since matrix metalloproteinases …