Brain metastases affect a significant percentage of patients with advanced extracranial
malignancies. Yet, the incidence of brain metastases remains poorly described, largely due …

Brain metastases from breast cancer (BCBM) constitute the second most common cause of
brain metastasis (BM), and the incidence of these frequently lethal lesions is currently …

PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for
clinical trials for fear that poor survival could mask the benefit of otherwise promising …

Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage
breast cancer is considered a curable disease; however, once distant metastasis occurs, the …

Brain metastases (BMs) are an important source of morbidity and mortality in patients with
metastatic breast cancer (BC). As survival of patients with advanced BC considerably …

Endocrine therapy (ET) is the cornerstone of management in hormone receptor (HR)+ breast
cancer (BC). Indeed, targeting the estrogen receptor (ER) signaling at different levels is a …

Expression of hormone receptor (HR) for estrogens (ER) and progesterone (PR) and HER2
remains the cornerstone to define the therapeutic strategy for breast cancer patients. We …

Background Predictive biomarkers are needed to identify oestrogen receptor-positive,
human epidermal growth factor receptor 2-negative (ER+/HER2-) metastatic breast cancer …

Background There is an increasing need for developing effective therapies for managing
intracranial disease in patients with human epidermal growth factor receptor 2-positive …

Simple Summary Breast cancer, the most common malignant tumor among women
worldwide, remains an incurable disease once it has spread to the brain. Past research has …