Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
The enigmatic HCN channels: A cellular neurophysiology perspective
P Mishra, R Narayanan - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
What physiological role does a slow hyperpolarization‐activated ion channel with mixed
cation selectivity play in the fast world of neuronal action potentials that are driven by …
cation selectivity play in the fast world of neuronal action potentials that are driven by …
Spatial learning impairments and discoordination of entorhinal‐hippocampal circuit coding following prolonged febrile seizures
ML Kloc, Y Chen, JM Daglian, GL Holmes… - …, 2023 - Wiley Online Library
How the development and function of neural circuits governing learning and memory are
affected by insults in early life remains poorly understood. The goal of this study was to …
affected by insults in early life remains poorly understood. The goal of this study was to …
Dynorphin/kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner
HE Yarur, SM Casello, VS Tsai, J Enriquez-Traba… - Molecular …, 2023 - nature.com
The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex
Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …
Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit
The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus,
directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important …
directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important …
Ion‐channel degeneracy and heterogeneities in the emergence of complex spike bursts in CA3 pyramidal neurons
R Roy, R Narayanan - The Journal of physiology, 2023 - Wiley Online Library
Complex spike bursting (CSB) is a characteristic electrophysiological signature exhibited by
several neuronal subtypes and has been implicated in neural plasticity, learning, perception …
several neuronal subtypes and has been implicated in neural plasticity, learning, perception …
Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study
Electroencephalography studies link sensory processing issues in schizophrenia to
increased noise level—noise here is background spontaneous activity—as measured by the …
increased noise level—noise here is background spontaneous activity—as measured by the …
Bioelectronic medicine: a multidisciplinary roadmap from biophysics to precision therapies
MA González-González, SV Conde… - Frontiers in Integrative …, 2024 - frontiersin.org
Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive
clinical benefits, alongside unique challenges. It consists of the modulation of the nervous …
clinical benefits, alongside unique challenges. It consists of the modulation of the nervous …
[图书][B] Electric Brain Signals: Foundations and Applications of Biophysical Modeling
It is common to study the electric activity of neurons by measuring the electric potential in the
extracellular space of the brain. However, interpreting such measurements requires …
extracellular space of the brain. However, interpreting such measurements requires …