The glyoxalase system is a ubiquitous enzymatic network which plays important roles in
biological life. It consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced …

Vitamin D deficiency has been clearly linked to major chronic diseases associated with
oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative …

Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant
nutritional and health benefits. It contains distinct molecular components with high …

Vitamin D deficiency has been linked to several major chronic diseases, such as
cardiovascular and neurodegenerative diseases, diabetes, and cancer, linked to oxidative …

Abstract Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic
origin affecting 0.5% of the population and characterized by abnormally enlarged and leaky …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the
cellular antioxidant defense system at the posttranscriptional level. During oxidative stress …

Abstract KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous
Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3 …

Hyperglycemia, a defining characteristic of diabetes, combined with oxidative stress, results
in the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that …

Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical
role in vascular morphogenesis and homeostasis. Its loss-of-function has been …

Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of
cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting …