Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Micronutrients, vitamins and minerals accessible from the diet, are essential for biologic
activity. Micronutrient status varies widely throughout pregnancy and across populations …

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …