Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis

CJ Gray, B Thomas, R Upton, LG Migas… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Diverse varieties of often heterogeneous glycans are ubiquitous in nature. They
play critical roles in recognition events, act as energy stores and provide structural stability at …

Hybrid ion mobility and mass spectrometry as a separation tool

MA Ewing, MS Glover, DE Clemmer - Journal of Chromatography A, 2016 - Elsevier
Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) has seen spectacular
growth over the last two decades. Increasing IMS sensitivity and capacity with improvements …

A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry

X Zheng, NA Aly, Y Zhou, KT Dupuis, A Bilbao… - Chemical …, 2017 - pubs.rsc.org
The confident identification of metabolites and xenobiotics in biological and environmental
studies is an analytical challenge due to their immense dynamic range, vast chemical space …

New frontiers for mass spectrometry based upon structures for lossless ion manipulations

YM Ibrahim, AM Hamid, L Deng, SVB Garimella… - Analyst, 2017 - pubs.rsc.org
Structures for lossless ion manipulations (SLIM) provide a new paradigm for efficient,
complex and extended gas phase ion manipulations. SLIM are created from electric fields …

Coupling front-end separations, ion mobility spectrometry, and mass spectrometry for enhanced multidimensional biological and environmental analyses

X Zheng, R Wojcik, X Zhang, YM Ibrahim… - Annual Review of …, 2017 - annualreviews.org
Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular
separations in the gas phase. Though IMS alone is useful, its coupling with mass …

Increasing selectivity and coverage in LC-MS based metabolome analysis

K Ortmayr, TJ Causon, S Hann… - TrAC Trends in Analytical …, 2016 - Elsevier
The term non-targeted metabolomics implies a global and unbiased analysis. This involves
the complex (and yet not routine) task of correct alignment and eventually annotation of …

Development of an ion mobility spectrometry-orbitrap mass spectrometer platform

YM Ibrahim, SVB Garimella, SA Prost, R Wojcik… - Analytical …, 2016 - ACS Publications
Complex samples benefit from multidimensional measurements where higher resolution
enables more complete characterization of biological and environmental systems. To …

Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?

TO Metz, ES Baker, EL Schymanski, RS Renslow… - Bioanalysis, 2017 - Taylor & Francis
Measuring the exposome remains a challenge due to the range and number of
anthropogenic molecules that are encountered in our daily lives, as well as the complex …

Achieving high resolution ion mobility separations using traveling waves in compact multiturn structures for lossless ion manipulations

AM Hamid, SVB Garimella, YM Ibrahim… - Analytical …, 2016 - ACS Publications
We report on ion mobility (IM) separations achievable using traveling waves (TW) in a
Structures for Lossless Ion Manipulations (SLIM) module having a 44 cm path length and 16 …

Utilizing drift tube ion mobility spectrometry for the evaluation of metabolites and xenobiotics

MT Odenkirk, ES Baker - Ion Mobility-Mass Spectrometry: Methods and …, 2020 - Springer
Metabolites and xenobiotics are small molecules with a molecular weight that often falls
below 600 Da. Over the last few decades, multiple small molecule databases have been …