The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Abstract Purpose of Review Skeletal muscle and bone are connected anatomically and
physiologically, and play a crucial role in human locomotion and metabolism. Historically …

Sarcopenia is a progressive, generalized skeletal muscle disorder characterized by
reduction of muscle mass and strength. It is associated with increased adverse outcomes …

Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

Muscle and bone are closely associated in both anatomy and function, but the mechanisms
that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted …

Most physiological functions originate with the communication between organs. Mouse
genetics has revived this holistic view of physiology through the identification of inter-organ …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

The prevalence of osteoporosis and sarcopenia is significantly higher in patients with liver
disease than in those without liver disease and osteoporosis and sarcopenia negatively …