Cognitive decline in Parkinson disease

D Aarsland, B Creese, M Politis… - Nature Reviews …, 2017 - nature.com
Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies

KA Jellinger - Journal of neural transmission, 2018 - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

KA Jellinger, AD Korczyn - BMC medicine, 2018 - Springer
Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the …

P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Alpha and beta synucleins: from pathophysiology to clinical application as biomarkers

L Barba, F Paolini Paoletti, G Bellomo… - Movement …, 2022 - Wiley Online Library
The synuclein family includes three neuronal proteins, named α‐synuclein, β‐synuclein, and
γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a …

Alpha-synuclein: mechanisms of release and pathology progression in synucleinopathies

IC Brás, TF Outeiro - Cells, 2021 - mdpi.com
The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy
pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis. The …

Serum NFL discriminates Parkinson disease from atypical parkinsonisms

TM Marques, A van Rumund, P Oeckl, HB Kuiperij… - Neurology, 2019 - AAN Enterprises
Objective To investigate the diagnostic value of serum neurofilament light chain (NFL) in
patients with clear signs of parkinsonism but whose specific diagnosis was yet uncertain …

Cognitive changes in prodromal Parkinson's disease: a review

S Fengler, I Liepelt‐Scarfone, K Brockmann… - Movement …, 2017 - Wiley Online Library
Although other nonmotor phenomena representing possible prodromal symptoms of
Parkinson's disease have been described in some detail, the occurrence and characteristics …

Finding useful biomarkers for Parkinson's disease

AS Chen-Plotkin, R Albin, R Alcalay… - Science translational …, 2018 - science.org
Finding useful biomarkers for Parkinson’s disease | Science Translational Medicine news
careers commentary Journals Science Science brought to you byGoogle Indexer Log in science …

Cerebrospinal fluid biomarkers for early and differential Alzheimer's disease diagnosis

M Bjerke, S Engelborghs - Journal of Alzheimer's Disease, 2018 - content.iospress.com
An accurate and early diagnosis of Alzheimer's disease (AD) is important to select optimal
patient care and is critical in current clinical trials targeting core AD neuropathological …