The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

Cocrystallization has been recognized as one of the most successful approaches to address
the stability problems of active pharmaceutical ingredients (APIs) in the past few decades …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Cocrystals are long known yet recently applied molecular entities. In the past decade, a
significant potential has been demonstrated by these novel solids in terms of modifying the …

The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …

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Introduction: Oral drug delivery is the most favored route of drug administration. However …

Cocrystals are crystalline single phase materials composed of two or more different
molecular and/or ionic compounds generally in a stoichiometric ratio which are neither …