In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …

The impact of malaria on global health has continually prompted the need to develop more
effective diagnostic strategies that could overcome deficiencies in accurate and early …

Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect
the liver for an initial round of replication before the emergence of pathogenic blood stages …

Obligate intracellular malaria parasites reside within a vacuolar compartment generated
during invasion which is the principal interface between pathogen and host. To subvert their …

Within the liver a single Plasmodium parasite transforms into thousands of blood-infective
forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are …

ABSTRACT The 10 Plasmodium 6‐Cys proteins have critical roles throughout parasite
development and are targets for antimalaria vaccination strategies. We analyzed the …