[HTML][HTML] Potential therapeutic agents to COVID-19: An update review on antiviral therapy, immunotherapy, and cell therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China,
in December 2020 and coronavirus disease 19 (COVID-19) was later announced as …
in December 2020 and coronavirus disease 19 (COVID-19) was later announced as …
[HTML][HTML] Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy
MDA Paskeh, M Entezari, C Clark, A Zabolian… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Normal cells depend on autophagy to maintain cellular homeostasis by recycling damaged
organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis …
organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis …
Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by optimized microtubule-associated protein 1 light chain 3 beta-recruiting coumarin analogs
Y Zeng, J Xiao, Y Xu, F Wei, L Tian, Y Gao… - Journal of medicinal …, 2023 - ACS Publications
Autophagy is an efficient and attractive protein degradation pathway in addition to the
ubiquitin-proteasome system. Herein, systematic optimization of coumarin analogs linked …
ubiquitin-proteasome system. Herein, systematic optimization of coumarin analogs linked …
Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
Temozolomide, simvastatin and acetylshikonin combination induces mitochondrial-dependent apoptosis in GBM cells, which is regulated by autophagy
Simple Summary Glioblastoma multiforme (GBM) is a deadly brain tumor. The current
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …
Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in …
Background The COVID-19 pandemic remains an emerging public health crisis with serious
adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 …
adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 …
Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in …
MO Welcome, D Dogo, NE Mastorakis - Inflammopharmacology, 2023 - Springer
Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …
Multifunctional pH-responsive nanogel for malaria and cancer treatment: hitting two targets with one arrow
Malaria and cancer have been considered deadly diseases around the world. Cancer and
malaria both have high incidence rates despite numerous research efforts to develop …
malaria both have high incidence rates despite numerous research efforts to develop …
Drug discovery inspired by bioactive small molecules from nature
S Kim, SW Lim, J Choi - Animal Cells and Systems, 2022 - Taylor & Francis
Natural products (NPs) have greatly contributed to the development of novel treatments for
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …
Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity
S Bartaula-Brevik, C Leitch… - Journal of Clinical …, 2023 - mdpi.com
Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is
expressed in primary acute myeloid leukemia cells (AML), but the expression varies …
expressed in primary acute myeloid leukemia cells (AML), but the expression varies …