Epigenetic regulation of macrophages: from homeostasis maintenance to host defense
S Chen, J Yang, Y Wei, X Wei - Cellular & molecular immunology, 2020 - nature.com
Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …
The differentiation and activation of macrophages require the timely regulation of gene …
LPS-induced cytokine production in human monocytes and macrophages
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …
immune-activating stimuli known. Here we review the current understanding of LPS effects …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
Interleukin-12 and the regulation of innate resistance and adaptive immunity
G Trinchieri - Nature Reviews Immunology, 2003 - nature.com
Abstract Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the
production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and …
production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and …
The role of mitophagy in innate immunity
Mitochondria are cellular organelles essential for multiple biological processes, including
energy production, metabolites biosynthesis, cell death, and immunological responses …
energy production, metabolites biosynthesis, cell death, and immunological responses …
mRNA is an endogenous ligand for Toll-like receptor 3
K Karikó, H Ni, J Capodici, M Lamphier… - Journal of Biological …, 2004 - ASBMB
Toll-like receptors (TLRs) are the basic signaling receptors of the innate immune system.
They are activated by molecules associated with pathogens or injured host cells and tissue …
They are activated by molecules associated with pathogens or injured host cells and tissue …
The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression
K De Bosscher, W Vanden Berghe… - Endocrine …, 2003 - academic.oup.com
The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …
important for homeostasis. A precise physiological control of inflammation allows a timely …
Recognition and signaling by toll-like receptors
Toll-like receptors (TLRs) are transmembrane proteins that detect invading pathogens by
binding conserved, microbially derived molecules and that induce signaling cascades for …
binding conserved, microbially derived molecules and that induce signaling cascades for …
A calculated response: control of inflammation by the innate immune system
GM Barton - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Inflammation is a rapid yet coordinated response that can lead to the destruction of microbes
and host tissue. Triggers capable of inducing an inflammatory response include tissue …
and host tissue. Triggers capable of inducing an inflammatory response include tissue …
Transcriptional regulation via the NF-κB signaling module
Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …
responses and immune function, comprises a family of dimeric transcription factors that …