The biology, function, and biomedical applications of exosomes

R Kalluri, VS LeBleu - Science, 2020 - science.org
BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …

Circulating biomarkers in patients with glioblastoma

J Müller Bark, A Kulasinghe, B Chua, BW Day… - British journal of …, 2020 - nature.com
Gliomas are the most common tumours of the central nervous system and the most
aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival …

Exosome: a significant nano-scale drug delivery carrier

H Peng, W Ji, R Zhao, J Yang, Z Lu, Y Li… - Journal of Materials …, 2020 - pubs.rsc.org
In recent years, due to the limitations of the nature of therapeutic agents, many synthetic
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …

A review on artificial intelligence and machine learning to improve cancer management and drug discovery

R Kumar, P Saha - International Journal for Research in Applied …, 2022 - ijrasb.com
Typical pharmacological effect screening techniques use diluted natural ingredients that do
not segregate active components. For the last two decades, contemporary medicine has …

[HTML][HTML] Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology

A Yokoi, T Ochiya - Seminars in cancer biology, 2021 - Elsevier
Extracellular vesicles (EVs) such as exosomes are released by all living cells and contain
diverse bioactive molecules, including nucleic acids, proteins, lipids, and metabolites …

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications

R Soffietti, C Bettegowda, IK Mellinghoff… - Neuro …, 2022 - academic.oup.com
Background There is an extensive literature highlighting the utility of blood-based liquid
biopsies in several extracranial tumors for diagnosis and monitoring. Methods The RANO …

Serum extracellular vesicle-derived circHIPK3 and circSMARCA5 are two novel diagnostic biomarkers for glioblastoma multiforme

M Stella, L Falzone, A Caponnetto, G Gattuso… - Pharmaceuticals, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most frequent and deadly human brain cancer. Early
diagnosis through non-invasive biomarkers may render GBM more easily treatable …

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

KC Pavani, T Meese, OB Pascottini… - Proceedings of the …, 2022 - National Acad Sciences
Extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) are important regulators of
embryo development to the blastocyst stage and beyond. Before implantation can take …

Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification

CL Maire, MM Fuh, K Kaulich, KD Fita, I Stevic… - Neuro …, 2021 - academic.oup.com
Background Genome-wide DNA methylation profiling has recently been developed into a
tool that allows tumor classification in central nervous system tumors. Extracellular vesicles …

The role of MiRNA in cancer: pathogenesis, diagnosis, and treatment

E Uzuner, GT Ulu, SB Gürler, Y Baran - miRNomics: MicroRNA Biology …, 2022 - Springer
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …