Granule cells of the cerebellum constitute the largest homogeneous neuronal population of
mammalian brain. Due to their postnatal generation and the feasibility of well characterized …

Abstract d-Serine (d-Ser) is an endogenous co-agonist for NMDA receptors and regulates
neurotransmission and synaptic plasticity in the forebrain. d-Ser is also found in the …

Nitric oxide (NO) is a diffusible, multifunctional signaling molecule found in many areas of
the brain. NO signaling is involved in a wide array of neurophysiological functions including …

Ts65Dn mice, trisomic for a portion of chromosome 16 segmentally homologous to human
chromosome 21, are an animal model for Down's syndrome and related neurodegenerative …

The diffusible chemical messenger nitric oxide (NO) is involved in neuronal plasticity and it
is, therefore, supposed to play a role in brain development. A shortage of NO during the …

The Lot1 gene encodes a zinc finger protein that, in vitro, concurrently regulates apoptosis
and cell cycle arrest and belongs to a recently identified family of proteins with oncogenic …

Tottering, rolling Nagoya, and leaner mutant mice all exhibit cerebellar ataxia to varying
degrees, from mild (tottering mice) to severe (leaner mice). Collectively, these mice are …

In this study, we show that one single dose of gamma-irradiation at birth induces an
inhibition of the cerebellar calcium dependent nitric oxide synthase (NOS) activity, probably …

Acute and long-term complications can occur in patients receiving radiation therapy. It has
been suggested that cytoprotection might decrease the incidence and severity of therapy …

The effects of prenatal CO exposure (150 ppm from days 0 to 20 of pregnancy) on the
postnatal development of hippocampal neuronal NO synthase (n NOS) and haem …