Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …

Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on
capture of polyadenylated RNAs and cannot recover proteins that interact with …

The establishment of a functioning neuronal network is a crucial step in neural development.
During this process, neurons extend neurites—axons and dendrites—to meet other neurons …

Stretch-growth has been defined as a process that extends axons via the application of
mechanical forces. In the present article, we used a protocol based on magnetic …

Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

The axon is a sophisticated macromolecular machine composed of interrelated parts that
transmit signals like spur gears transfer motion between parallel shafts. The growth cone is a …

The polarization of neurons into axons and dendrites depends on extracellular cues,
intracellular signaling, cytoskeletal rearrangements, and polarized transport, but the …

Regeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent
decay of permissive conditions restricts the regrowth of the mature CNS after an injury …

Neurons have a unique polarized nature that must adapt to environmental changes
throughout their lifespan. During embryonic development, axon elongation is led by the …