Tissue morphogenesis through dynamic cell and matrix interactions
Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …
All-covalent nuclease-resistant and hydrogel-tethered DNA hairpin probes map pN cell traction forces
Cells sense and respond to the physical properties of their environment through receptor-
mediated signaling, a process known as mechanotransduction, which can modulate critical …
mediated signaling, a process known as mechanotransduction, which can modulate critical …
Determination of single-molecule loading rate during mechanotransduction in cell adhesion
Cells connect with their environment through surface receptors and use physical tension in
receptor–ligand bonds for various cellular processes. Single-molecule techniques have …
receptor–ligand bonds for various cellular processes. Single-molecule techniques have …
Anoikis in cell fate, physiopathology, and therapeutic interventions
J Mei, XY Jiang, HX Tian, DC Rong, JN Song… - MedComm, 2024 - Wiley Online Library
The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a
particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis …
particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis …
RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes
Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …
Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo
S Jeong, W Shin, M Park, J Lee, Y Lim, K Noh… - Nano …, 2023 - ACS Publications
As a new enabling nanotechnology tool for wireless, target-specific, and long-distance
stimulation of mechanoreceptors in vivo, here we present a hydrogel magnetomechanical …
stimulation of mechanoreceptors in vivo, here we present a hydrogel magnetomechanical …
Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications
T He, D Giacomini, A Tolomelli, M Baiula, L Gentilucci - Biomedicines, 2024 - mdpi.com
Integrins are heterodimeric cell-surface receptors that regulate cell–cell adhesion and
cellular functions through bidirectional signaling. On the other hand, anomalous trafficking of …
cellular functions through bidirectional signaling. On the other hand, anomalous trafficking of …
Multiscale computational framework to investigate integrin mechanosensing and cell adhesion
AR Montes, G Gutierrez, A Buganza Tepole… - Journal of Applied …, 2023 - pubs.aip.org
a) Authors to whom correspondence should be addressed: abuganza@ purdue. edu.
Tepole Mechanics and Mechanobiology Lab: engineering. purdue. edu/tepolelab/mofrad …
Tepole Mechanics and Mechanobiology Lab: engineering. purdue. edu/tepolelab/mofrad …
Defining integrin tension required for chemotaxis of metastatic breast cancer cells in confinement
Cancer metastasis is affected by chemical factors and physical cues. From cell adhesion to
migration, mechanical tension applied to integrin expresses on the cell membrane and …
migration, mechanical tension applied to integrin expresses on the cell membrane and …
Develop Tandem Tension Sensor to Gauge Integrin-Transmitted Molecular Forces
G Niraula, A Pyne, X Wang - ACS sensors, 2024 - ACS Publications
DNA-based tension sensors have innovated the imaging and calibration of
mechanosensitive receptor-transmitted molecular forces, such as integrin tensions …
mechanosensitive receptor-transmitted molecular forces, such as integrin tensions …