Tissue morphogenesis through dynamic cell and matrix interactions

D Wu, KM Yamada, S Wang - Annual Review of Cell and …, 2023 - annualreviews.org
Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

All-covalent nuclease-resistant and hydrogel-tethered DNA hairpin probes map pN cell traction forces

SA Rashid, Y Dong, H Ogasawara… - … Applied Materials & …, 2023 - ACS Publications
Cells sense and respond to the physical properties of their environment through receptor-
mediated signaling, a process known as mechanotransduction, which can modulate critical …

Determination of single-molecule loading rate during mechanotransduction in cell adhesion

MH Jo, P Meneses, O Yang, CC Carcamo, S Pangeni… - Science, 2024 - science.org
Cells connect with their environment through surface receptors and use physical tension in
receptor–ligand bonds for various cellular processes. Single-molecule techniques have …

Anoikis in cell fate, physiopathology, and therapeutic interventions

J Mei, XY Jiang, HX Tian, DC Rong, JN Song… - MedComm, 2024 - Wiley Online Library
The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a
particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis …

RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes

MR Pawlak, AT Smiley, MP Ramirez, MD Kelly… - Nature …, 2023 - nature.com
Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo

S Jeong, W Shin, M Park, J Lee, Y Lim, K Noh… - Nano …, 2023 - ACS Publications
As a new enabling nanotechnology tool for wireless, target-specific, and long-distance
stimulation of mechanoreceptors in vivo, here we present a hydrogel magnetomechanical …

Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications

T He, D Giacomini, A Tolomelli, M Baiula, L Gentilucci - Biomedicines, 2024 - mdpi.com
Integrins are heterodimeric cell-surface receptors that regulate cell–cell adhesion and
cellular functions through bidirectional signaling. On the other hand, anomalous trafficking of …

Multiscale computational framework to investigate integrin mechanosensing and cell adhesion

AR Montes, G Gutierrez, A Buganza Tepole… - Journal of Applied …, 2023 - pubs.aip.org
a) Authors to whom correspondence should be addressed: abuganza@ purdue. edu.
Tepole Mechanics and Mechanobiology Lab: engineering. purdue. edu/tepolelab/mofrad …

Defining integrin tension required for chemotaxis of metastatic breast cancer cells in confinement

Y Kim, LTH Tram, KA Kim… - Advanced Healthcare …, 2023 - Wiley Online Library
Cancer metastasis is affected by chemical factors and physical cues. From cell adhesion to
migration, mechanical tension applied to integrin expresses on the cell membrane and …

Develop Tandem Tension Sensor to Gauge Integrin-Transmitted Molecular Forces

G Niraula, A Pyne, X Wang - ACS sensors, 2024 - ACS Publications
DNA-based tension sensors have innovated the imaging and calibration of
mechanosensitive receptor-transmitted molecular forces, such as integrin tensions …