Site-selective modification strategies in antibody–drug conjugates
SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
Novel insights into the function of CD24: A driving force in cancer
CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …
CD24: a novel target for cancer immunotherapy
E Panagiotou, NK Syrigos, A Charpidou… - Journal of Personalized …, 2022 - mdpi.com
Cluster of differentiation 24 (CD24) is a small, highly glycosylated cell adhesion protein that
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …
Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma
G Moldenhauer, AV Salnikov, S Lüttgau… - Journal of the …, 2012 - academic.oup.com
Background Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many
cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed no …
cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed no …
Antibody conjugates: from heterogeneous populations to defined reagents
Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of
therapeutics. Even if naked antibodies have proven their value as successful …
therapeutics. Even if naked antibodies have proven their value as successful …
Terpinen-4-ol: A novel and promising therapeutic agent for human gastrointestinal cancers
S Shapira, S Pleban, D Kazanov, P Tirosh, N Arber - PloS one, 2016 - journals.plos.org
Background Terpinen-4-ol, a naturally occurring monoterpene is the main bioactive
component of tea-tree oil and has been shown to have many biological activities. Aim To …
component of tea-tree oil and has been shown to have many biological activities. Aim To …
CD24 blockade as a novel strategy for cancer treatment
Y Wang, H Yu, M Yu, H Liu, B Zhang, Y Wang… - International …, 2023 - Elsevier
The CD24 protein is a heat-stable protein with a small core that undergoes extensive
glycosylation. It is expressed on the surface of various normal cells, including lymphocytes …
glycosylation. It is expressed on the surface of various normal cells, including lymphocytes …
Emerging Immune Checkpoint molecules on Cancer cells: CD24 and CD200
SY Moon, M Han, G Ryu, SA Shin, JH Lee… - International Journal of …, 2023 - mdpi.com
Cancer immunotherapy strategies are based on the utilization of immune checkpoint
inhibitors to instigate an antitumor immune response. The efficacy of immune checkpoint …
inhibitors to instigate an antitumor immune response. The efficacy of immune checkpoint …
[HTML][HTML] CD24 as a potential therapeutic target in patients with B-cell leukemia and lymphoma: current insights
SL Christian - OncoTargets and therapy, 2022 - ncbi.nlm.nih.gov
CD24 is a highly glycosylated glycophosphatidylinositol (GPI)-anchored protein that is
expressed in many types of differentiating cells and some mature cells of the immune system …
expressed in many types of differentiating cells and some mature cells of the immune system …
The bacterial instrument as a promising therapy for colon cancer
Objective Colon cancer is a great health concern worldwide, as it is the second leading
cause of cancer-related death. Conventional treatment of cancer such as surgery …
cause of cancer-related death. Conventional treatment of cancer such as surgery …