Site-selective modification strategies in antibody–drug conjugates

SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Novel insights into the function of CD24: A driving force in cancer

P Altevogt, M Sammar, L Hüser… - International journal of …, 2021 - Wiley Online Library
CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …

CD24: a novel target for cancer immunotherapy

E Panagiotou, NK Syrigos, A Charpidou… - Journal of Personalized …, 2022 - mdpi.com
Cluster of differentiation 24 (CD24) is a small, highly glycosylated cell adhesion protein that
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …

Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma

G Moldenhauer, AV Salnikov, S Lüttgau… - Journal of the …, 2012 - academic.oup.com
Background Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many
cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed no …

Antibody conjugates: from heterogeneous populations to defined reagents

P Dennler, E Fischer, R Schibli - Antibodies, 2015 - mdpi.com
Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of
therapeutics. Even if naked antibodies have proven their value as successful …

Terpinen-4-ol: A novel and promising therapeutic agent for human gastrointestinal cancers

S Shapira, S Pleban, D Kazanov, P Tirosh, N Arber - PloS one, 2016 - journals.plos.org
Background Terpinen-4-ol, a naturally occurring monoterpene is the main bioactive
component of tea-tree oil and has been shown to have many biological activities. Aim To …

CD24 blockade as a novel strategy for cancer treatment

Y Wang, H Yu, M Yu, H Liu, B Zhang, Y Wang… - International …, 2023 - Elsevier
The CD24 protein is a heat-stable protein with a small core that undergoes extensive
glycosylation. It is expressed on the surface of various normal cells, including lymphocytes …

Emerging Immune Checkpoint molecules on Cancer cells: CD24 and CD200

SY Moon, M Han, G Ryu, SA Shin, JH Lee… - International Journal of …, 2023 - mdpi.com
Cancer immunotherapy strategies are based on the utilization of immune checkpoint
inhibitors to instigate an antitumor immune response. The efficacy of immune checkpoint …

[HTML][HTML] CD24 as a potential therapeutic target in patients with B-cell leukemia and lymphoma: current insights

SL Christian - OncoTargets and therapy, 2022 - ncbi.nlm.nih.gov
CD24 is a highly glycosylated glycophosphatidylinositol (GPI)-anchored protein that is
expressed in many types of differentiating cells and some mature cells of the immune system …

The bacterial instrument as a promising therapy for colon cancer

A Yaghoubi, M Khazaei, A Avan, SM Hasanian… - International journal of …, 2020 - Springer
Objective Colon cancer is a great health concern worldwide, as it is the second leading
cause of cancer-related death. Conventional treatment of cancer such as surgery …