High-throughput genetic screens interfering with gene expression are invaluable tools to
identify gene function and phenotype-to-genotype interactions. Implementing such screens …

Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …

The natural history of small-cell lung cancer (SCLC) includes rapid evolution from
chemosensitivity to chemoresistance, although mechanisms underlying this evolution …

RNA interference (RNAi) is an extremely useful tool for inhibiting gene expression. It can be
triggered by transfected synthetic small interfering RNA (siRNA) or by expressed small …

Genomics has provided a detailed structural description of the cancer genome. Identifying
oncogenic drivers that work primarily through dosage changes is a current challenge …

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional
dysregulation that results in a block in differentiation and increased malignant self-renewal …

Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key
factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 …

Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular
pathways that enable cancer cells to selectively grow in the brain microenvironment are …

Motivation Summary graphics for RNA-sequencing and microarray gene expression
analyses may contain upwards of tens of thousands of points. Details about certain genes or …

To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-
Cas9 knockout (KO) screens in patient-derived GBM stem-like cells (GSCs) and human …