Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Ubiquitination represents a post-translational modification (PTM) essential for the
maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein …

The deubiquitinating enzyme (DUB)–mediated cleavage of ubiquitin plays a critical role in
balancing protein synthesis and degradation. Ubiquitin-specific protease 4 (USP4), a …

This second edition integrates the more technical and mathematical aspects of
bioinformatics with concrete examples of their application to current research problems in …

Cancer remains one of the major culprits causing disease-related deaths and leads to a
high morbidity and similar mortality. Insidious onset, difficult early detection and a lack of …

Abstract Ubiquitin-specific protease 15 (USP15) is a widely expressed deubiquitylase that
has been implicated in diverse cellular processes in cancer. Here we identify topoisomerase …

Ubiquitin and ubiquitin-like molecules are attached to and removed from cellular proteins in
a dynamic and highly regulated manner. Deubiquitinating enzymes are critical to this …

Abstract Ubiquitin-specific protease 4 (USP4) is pivotal in negatively regulating the Toll-like
receptor (TLR) signaling-mediated innate immune response. Although USP4 has been well …

Two major stumbling blocks exist in high-throughput sequencing (HTS) data analysis. The
first is the sheer file size, typically in gigabytes when uncompressed, causing problems in …

Introns in different genes, or even different introns within the same gene, often have different
splice sites and differ in splicing efficiency (SE). One expects mass-transcribed genes to …