Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

In smooth muscle cells (SMCs), the intracellular chloride ion (Cl−) concentration is high due
to accumulation by Cl−/HCO 3− exchange and Na+–K+–Cl− cotransportation. The …

The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …

BACKGROUND: Aortic dissection (AD) is a fatal cardiovascular disorder without effective
medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant …

In smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major
anionic channel. Opening of these channels leads to chloride efflux and depolarization of …

The presence of Ca 2+-activated Cl− channels (CaCCs) in vascular smooth muscle cells
(SMCs) is well established. Their molecular identity is, however, elusive. Two distinct Ca 2+ …

Recent studies suggest that primary changes in vascular resistance can cause sustained
changes in arterial blood pressure. In this review, we summarize current knowledge about …

Numerous mediators and drugs regulate blood flow or arterial pressure by acting on
vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to …

Rhythmical contractility of blood vessels was first observed in bat wing veins by Jones
(Philos Trans R Soc Lond 1852: 142, 131–136), and subsequently described in arteries and …

Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of
pulmonary hypertension (PH) and is believed to be the consequence of enhanced …