Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

H19 long non-coding RNA (lncRNA) has many functions in cancer. Some studies have
reported that H19 acts as an oncogene and is involved in cancer progression by activating …

Despite significant advances made in epigenetic research in recent decades, many
questions remain unresolved, especially concerning cause and consequence of epigenetic …

Imprinting is defined as the parental allele‐specific expression of a very limited set of genes
(about 50–80). This regulation depends upon an epigenetic marking of parental alleles …

Zinc-finger proteins (ZFPs) that recognize novel DNA sequences are the basis of a powerful
technology platform with many uses in drug discovery and therapeutics. These proteins …

KOC (K homology domain containing protein o verexpressed in c ancer) is a novel oncofetal
RNA-binding protein highly expressed in pancreatic carcinomas. Recently, Corixa …

MicroRNAs (miRNAs) are a recently discovered class of noncoding genes that regulate the
translation of target mRNA. More than 300 miRNAs have now been discovered in humans …

Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over
cell divisions, and play important roles in carcinogenesis. Aberrant methylation of CpG …

The Cys2His2 zinc finger is one of the most common DNA-binding motifs in Eukaryota. A
simple mode of DNA recognition by the Cys2His2 zinc finger domain provides an ideal …