Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Despite its very low level in humans, selenium plays an important and unique role among
the (semi) metal trace essential elements because it is the only one for which incorporation …

The endoplasmic reticulum (ER) is the major folding compartment for secreted and
membrane proteins and is the site of a specific chaperone system, the calnexin cycle, for …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Se is an unusual trace element in having its own codon in mRNA that specifies its insertion
into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large …

The objective of this study was to investigate the associations between selenium exposure
and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and …

Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

Recent identification of new selenocysteine-containing proteins has revealed relationships
between the two trace elements selenium (Se) and iodine and the hormone network …