[HTML][HTML] Cellular Plasticity in Mammary Gland Development and Breast Cancer

MN Wicker, KU Wagner - Cancers, 2023 - mdpi.com
Simple Summary For many decades, the cellular and molecular mechanisms that
orchestrate the differentiation of epithelial subtypes in the mammary gland have been a …

[HTML][HTML] Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells

PD Rädler, BL Wehde, AA Triplett, H Shrestha… - Nature …, 2021 - nature.com
Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of
mostly triple-negative mammary tumor cells that possess stem cell-like and mesenchymal …

Limiting transactivator amounts contribute to transgene mosaicism in Tet-on all-in-one systems

AG Duran, M Schwestka, TZ Nazari-Shafti… - ACS Synthetic …, 2022 - ACS Publications
MicroRNAs play an essential role in cell homeostasis and have been proposed as
therapeutic agents. One strategy to deliver microRNAs is to genetically engineer target cells …

[HTML][HTML] CRISPR editing enables consequential tag-activated MicroRNA-mediated endogene deactivation

PL Papasavva, P Patsali, CC Loucari, R Kurita… - International Journal of …, 2022 - mdpi.com
Molecular therapies and functional studies greatly benefit from spatial and temporal
precision of genetic intervention. We therefore conceived and explored tag-activated …

The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer

PD Raedler - 2020 - digitalcommons.unmc.edu
Breast cancers of the claudin-low subtype make up a substantial portion of triple-negative
breast cancers and have stem cell-like and mesenchymal features. Although it has been …