On the simulation of mitral valve function in health, disease, and treatment
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
A noninvasive method for the determination of in vivo mitral valve leaflet strains
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
Development of a functionally equivalent model of the mitral valve chordae tendineae through topology optimization
Ischemic mitral regurgitation (IMR) is a currently prevalent disease in the US that is projected
to become increasingly common as the aging population grows. In recent years, image …
to become increasingly common as the aging population grows. In recent years, image …
Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair
Mechanical stress is one of the major aetiological factors underlying soft-tissue remodelling,
especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress …
especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress …
In vivo assessment of mitral valve leaflet remodelling following myocardial infarction
Abstract Each year, more than 40,000 people undergo mitral valve (MV) repair surgery
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …
Simulation of mitral valve plasticity in response to myocardial infarction
Left ventricular myocardial infarction (MI) has broad and debilitating effects on cardiac
function. In many cases, MI leads to ischemic mitral regurgitation (IMR), a condition …
function. In many cases, MI leads to ischemic mitral regurgitation (IMR), a condition …
Multi-resolution geometric modeling of the mitral heart valve leaflets
An essential element of cardiac function, the mitral valve (MV) ensures proper directional
blood flow between the left heart chambers. Over the past two decades, computational …
blood flow between the left heart chambers. Over the past two decades, computational …
On the role of predicted in vivo mitral valve interstitial cell deformation on its biosynthetic behavior
Ischemic mitral regurgitation (IMR), a frequent complication of myocardial infarction, is
characterized by regurgitation of blood from the left ventricle back into the left atrium …
characterized by regurgitation of blood from the left ventricle back into the left atrium …
The three-dimensional microenvironment of the mitral valve: insights into the effects of physiological loads
Introduction In the mitral valve (MV), numerous pathological factors, especially those
resulting from changes in external loading, have been shown to affect MV structure and …
resulting from changes in external loading, have been shown to affect MV structure and …