Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts
and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside …

Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its
unique mechanical properties, tunable biodegradation rate and the ability to support the …

Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that
byproducts from joint replacements induce an inflammatory reaction that can result in …

As bones are levers for skeletal muscle to exert forces, both are complementary and
essential for locomotion and individual autonomy. In the past decades, the idea of a bone …