Myogenic cells in the body of vertebrates derive from the dorsal somite, the dermomyotome,
where multipotent cells are present. Regulation of cell fate choice is discussed, as is that of …

Histone methylation regulates chromatin structure and transcription. The recently identified
histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to …

Animal body plan arises during gastrulation and organogenesis by the coordination of
inductive events and cell movements. Several signaling pathways, such as BMP, FGF …

During vertebrate gastrulation, convergence and extension (C&E) movements narrow and
lengthen the embryonic tissues, respectively. In zebrafish, regional differences of C&E …

Vitamin E (VitE) deficiency results in embryonic lethality. Knockdown of the gene ttpa
encoding for the VitE regulatory protein [α-tocopherol transfer protein (α-TTP)] in zebrafish …

During vertebrate gastrulation, convergence and extension cell movements are coordinated
with the anteroposterior and mediolateral embryonic axes. Wnt planar cell polarity …

Bcl-2 proteins are acknowledged as key regulators of programmed cell death. However,
increasing data suggest additional roles, including regulation of the cell cycle, metabolism …

The etiology of mitochondrial disease is poorly understood. Furthermore, treatment options
are limited, and diagnostic methods often lack the sensitivity to detect disease in its early …

BACKGROUND: The phenotype of embryos exposed to ethanol is complex and likely due to
multiple alterations in developmental pathways. We have previously demonstrated that …

CTCF nuclear factor regulates many aspects of gene expression, largely as a transcriptional
repressor or via insulator function. Its roles in cellular differentiation are not clear. Here we …