Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a
phosphatase/phosphotransferase family. Mammalian LPPs consist of three isoforms: LPP1 …

Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate
from lysophosphatidylcholine, the most abundant phospholipid in blood plasma …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

While normal angiogenesis is critical for development and tissue growth, pathological
angiogenesis is important for the growth and spread of cancers by supplying nutrients and …

Rationale: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane
protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic …

Biomechanical cues dynamically control major cellular processes, but whether genetic
variants actively participate in mechanosensing mechanisms remains unexplored. Vascular …

Mammalian macrophages can adopt polarization states that, depending on the exact stimuli
present in their extracellular environment, can lead to very different functions. Although …