Cancer is currently ineffectively treated using therapeutic drugs, and is also able to resist
drug action, resulting in increased side effects following drug treatment. A novel therapeutic …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Introduction The biological membranes as natural permeable barriers are required for
survival and function of living cells. However, these natural barriers could be a major …

Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …

In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …

Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Based on their tunable physicochemical properties and the possibility of producing cell-
specific platforms through surface modification with functional biomolecules, nanoparticles …