Global burden of hepatitis B virus: current status, missed opportunities and a call for action

YC Hsu, DQ Huang, MH Nguyen - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is
the leading aetiology of cirrhosis and liver cancer globally. Major medical complications also …

Immunobiology and pathogenesis of hepatitis B virus infection

M Iannacone, LG Guidotti - Nature Reviews Immunology, 2022 - nature.com
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Epidemiology and surveillance for hepatocellular carcinoma: New trends

AG Singal, P Lampertico, P Nahon - Journal of hepatology, 2020 - Elsevier
The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although
its incidence and mortality are rapidly rising in the United States and Europe. With the …

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

A Kramvis, KM Chang, M Dandri, P Farci… - Nature Reviews …, 2022 - nature.com
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one
million people die annually from HBV-related causes, including liver cancer. Although there …

All about the RNA: interferon-stimulated genes that interfere with viral RNA processes

E Yang, MMH Li - Frontiers in immunology, 2020 - frontiersin.org
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Strand displacement amplification assisted CRISPR-Cas12a strategy for colorimetric analysis of viral nucleic acid

S Gong, S Zhang, X Wang, J Li, W Pan, N Li… - Analytical …, 2021 - ACS Publications
The development of a sensitive, facile, and cost-effective colorimetric method is of great
significance for the point-of-care testing of viral nucleic acid. Herein, we reported a strand …

HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression

Y Wang, M Zhao, L Zhao, Y Geng, G Li, L Chen, J Yu… - Cancer Research, 2023 - AACR
Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis is a
type of iron-mediated cell death that can suppress liver transformation. Previous studies …

Supervised machine learning models for liver disease risk prediction

E Dritsas, M Trigka - Computers, 2023 - mdpi.com
The liver constitutes the largest gland in the human body and performs many different
functions. It processes what a person eats and drinks and converts food into nutrients that …

The cell biology of the hepatocyte: A membrane trafficking machine

RJ Schulze, MB Schott, CA Casey, PL Tuma… - Journal of Cell …, 2019 - rupress.org
The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus

F Andreata, KD Moynihan, V Fumagalli… - Science Translational …, 2024 - science.org
CD8+ T cells are key antiviral effectors against hepatitis B virus (HBV), yet their number and
function can be compromised in chronic infections. Preclinical HBV models displaying CD8+ …