Transcriptional and epigenomic regulation of adipogenesis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
[HTML][HTML] Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos
R Xu, S Li, Q Wu, C Li, M Jiang, L Guo, M Chen, L Yang… - Cell Stem Cell, 2022 - cell.com
Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …
Toxoplasma Effectors Targeting Host Signaling and Transcription
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
[HTML][HTML] Epigenetics in cancer therapy and nanomedicine
A Roberti, AF Valdes, R Torrecillas, MF Fraga… - Clinical …, 2019 - Springer
The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …
Epitranscriptomics in metabolic disease
Y Matsumura, FY Wei, J Sakai - Nature Metabolism, 2023 - nature.com
While epigenetic modifications of DNA and histones play main roles in gene transcription
regulation, recently discovered post-transcriptional RNA modifications, known as …
regulation, recently discovered post-transcriptional RNA modifications, known as …
[HTML][HTML] Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses
G Gay, L Braun, MP Brenier-Pinchart… - The Journal of …, 2016 - ncbi.nlm.nih.gov
An early hallmark of Toxoplasma gondii infection is the rapid control of the parasite
population by a potent multifaceted innate immune response that engages resident and …
population by a potent multifaceted innate immune response that engages resident and …
[HTML][HTML] Extracellular acidic pH activates the sterol regulatory element-binding protein 2 to promote tumor progression
A Kondo, S Yamamoto, R Nakaki, T Shimamura… - Cell reports, 2017 - cell.com
Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play
critical roles in cancer progression. However, the role of acidic extracellular pH in cancer …
critical roles in cancer progression. However, the role of acidic extracellular pH in cancer …