The human gene catalogue is essentially complete, but we lack an equivalently vetted
inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers …

Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA,,,–and contain
genetic variations associated with diseases and phenotypic traits,–. We created high …

Abstract Development, differentiation and response to environmental stimuli are
characterized by sequential changes in cellular state initiated by the de novo binding of …

Summary Mapping DNase I hypersensitive (HS) sites is an accurate method of identifying
the location of genetic regulatory elements, including promoters, enhancers, silencers …

The combinatorial cross-regulation of hundreds of sequence-specific transcription factors
(TFs) defines a regulatory network that underlies cellular identity and function. Here we use …

Eviction or destabilization of nucleosomes from chromatin is a hallmark of functional
regulatory elements in eukaryotic genomes. Historically identified by nuclease …

GLOBIN GENES Hemoglobin is composed of heme residues and two chains each of a-like
and, B-like globin polypeptides. Each type of chain is encoded by a family of genes under …

We have characterized an element near the 5'boundary of the chicken~-globin domain that
insulates a reporter gene from the activating effects of a nearby p-globin locus control region …

This review synthesizes a subset of human epidemiologic and experimental animal studies
that suggest that early nutrition affects susceptibility to chronic diseases in adulthood. These …