Opportunities and challenges of using metagenomic data to bring uncultured microbes into cultivation
Although there is now an extensive understanding of the diversity of microbial life on earth
through culture-independent metagenomic DNA sequence analyses, the isolation and …
through culture-independent metagenomic DNA sequence analyses, the isolation and …
The sponge holobiont in a changing ocean: from microbes to ecosystems
The recognition that all macroorganisms live in symbiotic association with microbial
communities has opened up a new field in biology. Animals, plants, and algae are now …
communities has opened up a new field in biology. Animals, plants, and algae are now …
METABOLIC: high-throughput profiling of microbial genomes for functional traits, metabolism, biogeochemistry, and community-scale functional networks
Background Advances in microbiome science are being driven in large part due to our
ability to study and infer microbial ecology from genomes reconstructed from mixed …
ability to study and infer microbial ecology from genomes reconstructed from mixed …
Uncertainty in the timing of origin of animals and the limits of precision in molecular timescales
The timing of divergences among metazoan lineages is integral to understanding the
processes of animal evolution, placing the biological events of species divergences into the …
processes of animal evolution, placing the biological events of species divergences into the …
IMNGS: a comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies
I Lagkouvardos, D Joseph, M Kapfhammer, S Giritli… - Scientific reports, 2016 - nature.com
Abstract The SRA (Sequence Read Archive) serves as primary depository for massive
amounts of Next Generation Sequencing data and currently host over 100,000 16S rRNA …
amounts of Next Generation Sequencing data and currently host over 100,000 16S rRNA …
Vitamin B12 as a modulator of gut microbial ecology
The microbial mechanisms and key metabolites that shape the composition of the human
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …
An environmental bacterial taxon with a large and distinct metabolic repertoire
Cultivated bacteria such as actinomycetes are a highly useful source of biomedically
important natural products. However, such 'talented'producers represent only a minute …
important natural products. However, such 'talented'producers represent only a minute …
Genomic insights into the marine sponge microbiome
U Hentschel, J Piel, SM Degnan… - Nature Reviews …, 2012 - nature.com
Marine sponges (phylum Porifera) often contain dense and diverse microbial communities,
which can constitute up to 35% of the sponge biomass. The genome of one sponge …
which can constitute up to 35% of the sponge biomass. The genome of one sponge …
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology
WH Gerwick, BS Moore - Chemistry & biology, 2012 - cell.com
Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …
secondary metabolites, several of which have inspired the development of new classes of …
Present and future of culturing bacteria
J Overmann, B Abt, J Sikorski - Annual review of microbiology, 2017 - annualreviews.org
The cultivation of bacteria is highly biased toward a few phylogenetic groups. Many of the
currently underexplored bacterial lineages likely have novel biosynthetic pathways and …
currently underexplored bacterial lineages likely have novel biosynthetic pathways and …