Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft
recipient and AIDS patients. More recently, it has been recognized as a pathogen for those …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Individuals living with HIV who are optimally treated with combination antiretroviral therapy
(cART) can now lead an extended life. In spite of this remarkable survival benefit from viral …

To monitor inflammation in a meaningful way, the markers used must be valid: they must
reflect the inflammatory process under study and they must be predictive of future health …

The immune systems of men and women differ in significant ways, especially after puberty.
In particular, females are generally more prone to autoimmunity, but experience lower rates …

The concept of frailty as a medically distinct syndrome has evolved based on the clinical
experience of geriatricians and is clinically well recognizable. Frailty is a nonspecific state of …

Age-related frailty is an increasing societal challenge with growing emphasis on identifying
its underlying pathophysiology and prospects for intervention. We report findings from the …