Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
Advances in chalcones with anticancer activities
C Karthikeyan, N SH Narayana Moorthy… - Recent patents on …, 2015 - ingentaconnect.com
Chalcones are naturally occurring compounds exhibiting broad spectrum biological
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance
G Szakács, MD Hall, MM Gottesman… - Chemical …, 2014 - ACS Publications
The development of multidrug resistance (MDR) in patients suffering cancer remains a
significant clinical challenge, with drug efflux by ABC (ATP-binding cassette) transporters …
significant clinical challenge, with drug efflux by ABC (ATP-binding cassette) transporters …
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators
IF Zattoni, LC Delabio, J de Paula Dutra, DH Kita… - European journal of …, 2022 - Elsevier
The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …
be caused by different mechanisms, including the overexpression of ABC transporters in …
ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning
Breast cancer resistance protein (BCRP/ABCG2), an ATP-binding cassette (ABC) efflux
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …
Electroreductive upgradation of biomass into high-value chemicals and energy-intensive biofuels
Biomass has always been regarded as a latent resource owing to the lack of competitive
technology to convert it into an active substance. Electroreduction is considered as a …
technology to convert it into an active substance. Electroreduction is considered as a …
Updated chemical scaffolds of ABCG2 inhibitors and their structure-inhibition relationships for future development
ATP-binding cassette (ABC) transporters are pivotal for cell detoxification and survival.
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …
Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2
Multidrug resistance (MDR) often leads to a failure of cancer chemotherapy. Breast Cancer
Resistance Protein (BCRP/ABCG2), a member of the superfamily of ATP binding cassette …
Resistance Protein (BCRP/ABCG2), a member of the superfamily of ATP binding cassette …
Electrocatalytic hydrogenation of lignin monomer to methoxy-cyclohexanes with high faradaic efficiency
Developing efficient renewable electrocatalytic processes in chemical manufacturing is of
commercial interest, especially from biomass-derived feedstock. Selective electrocatalytic …
commercial interest, especially from biomass-derived feedstock. Selective electrocatalytic …