Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised
as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the …

Background The adaptation to hypoxia is mainly controlled by the HIF transcription factors.
Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients …

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for
peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA …

Cancer is a leading cause of death worldwide. As a common characteristic of cancer,
hypoxia is associated with poor prognosis due to enhanced tumor malignancy and …

Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour
biology, influencing cancer progression, the development of metastasis and patient …

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage,
suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme …

Purpose Human papillomavirus negative (HPV-ve) head and neck squamous cell
carcinoma (HNSCC) has a poor prognosis compared with HPV+ ve HNSCCs. Expression of …

The term hypoxia refers to any condition where insufficient oxygen is available and therefore
encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to …